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Brain Injury - Hypoxia Ischemia Due to Periventricular Leukomalacia (PVL).  The medical illustration series starts  with an orientation of the heart and brain within a child. Three views of the cut brain with the cerebral arteries and terminal branches show the collapse of the brain in three stages: normal anatomy, hypoxic ischemia (brain cell death) due to low blood pressure, and finally PVL in which the white matter is significantly decreased causing the brain to shrink.